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β(2) Integrin Induces TCR ζ–Syk–PLC-γ Phosphorylation and Paxillin-dependent Granule Polarization in Human NK cells()
Cytotoxic lymphocytes kill target cells through polarized release of the content of lytic granules at the immunological synapse. In human natural killer (NK) cells, signals for granule polarization and for degranulation can be uncoupled: Binding of β(2) integrin LFA-1 to ICAM is sufficient to induce...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3845901/ https://ncbi.nlm.nih.gov/pubmed/21270398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002438 |
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