Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome

PURPOSE: High-grade serous cancer (HGSC) is the most common cancer of the ovary and is characterized by chromosomal instability. Defects in homologous recombination repair (HRR) are associated with genomic instability in HGSC, and are exploited by therapy targeting DNA repair. Defective HRR causes u...

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Hauptverfasser: Wang, Zhigang C., Birkbak, Nicolai Juul, Culhane, Aedín C., Drapkin, Ronny, Fatima, Aquila, Tian, Ruiyang, Schwede, Matthew, Alsop, Kathryn, Daniels, Kathryn E., Piao, Huiying, Liu, Joyce, Etemadmoghadam, Dariush, Miron, Alexander, Salvesen, Helga B., Mitchell, Gillian, DeFazio, Anna, Quackenbush, John, Berkowitz, Ross S., Iglehart, J. Dirk, Bowtell, David D.L., Matulonis, Ursula A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205235/
https://ncbi.nlm.nih.gov/pubmed/22912389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0857
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