Increasing SK channel activity reverses ischemia-induced impairment of LTP

Global cerebral ischemia following cardiac arrest and cardiopulmonary resuscitation (CA/CPR) causes injury to hippocampal CA1 pyramidal neurons and impairs cognition. SK2 channels, expressed in CA1 pyramidal neurons, have been implicated as potential protective targets. Here we show that in mice, hi...

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Autori principali: Orfila, JE, Shimizu, K, Garske, AK, Deng, G, Maylie, J, Traystman, RJ, Quillinan, N, Adelman, JP, Herson, PS
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205199/
https://ncbi.nlm.nih.gov/pubmed/25080203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.12683
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