SK2 channels are neuroprotective for ischemia-induced neuronal cell death

In mouse hippocampal CA1 pyramidal neurons, the activity of synaptic small-conductance Ca(2+)-activated K(+) channels type 2 (SK2 channels) provides a negative feedback on N-methyl--aspartate receptors (NMDARs), reestablishing Mg(2+) block that reduces Ca(2+) influx. The well-established role of NMD...

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Autori principali: Allen, Duane, Nakayama, Shin, Kuroiwa, Masayuki, Nakano, Takaaki, Palmateer, Julie, Kosaka, Yasuharu, Ballesteros, Carmen, Watanabe, Masahiko, Bond, Chris T, Luján, Rafael, Maylie, James, Adelman, John P, Herson, Paco S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323193/
https://ncbi.nlm.nih.gov/pubmed/21712833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.90
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