Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features

OBJECTIVE: It was previously reported that docosahexanoic acid (DHA) reduces TNF-α-induced necrosis in L929 cells. However, the mechanisms underlying this reduction have not been investigated. The present study was designed to investigate cellular and biochemical mechanisms underlying the attenuatio...

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Hauptverfasser: Pacheco, Fabio J., Almaguel, Frankis G., Evans, Whitney, Rios-Colon, Leslimar, Filippov, Valery, Leoh, Lai S., Rook-Arena, Elizabeth, Mediavilla-Varela, Melanie, De Leon, Marino, Casiano, Carlos A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205108/
https://ncbi.nlm.nih.gov/pubmed/25095742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00011-014-0760-2
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