Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis

BACKGROUND: Genes of the Raf family encode kinases that are regulated by Ras and mediate cellular responses to growth signals. Recently, it was shown that activating mutations of BRaf are found with high frequency in human melanomas. The Ras family member most often mutated in melanoma is NRas. METH...

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Bibliografiske detaljer
Main Authors: Houben, Roland, Becker, Jürgen C, Kappel, Andreas, Terheyden, Patrick, Bröcker, Eva-B, Goetz, Rudolf, Rapp, Ulf R
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2004
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC420489/
https://ncbi.nlm.nih.gov/pubmed/15046639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3163-3-6
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