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Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle
Proper localization and anchorage of nuclei within skeletal muscle is critical for cellular function. Alterations in nuclear anchoring proteins modify a number of cellular functions including mechanotransduction, nuclear localization, chromatin positioning/compaction and overall organ function. In s...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4204769/ https://ncbi.nlm.nih.gov/pubmed/24943590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu310 |
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