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Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells
BACKGROUND: Cells harboring BRCA1/BRCA2 mutations are hypersensitive to inhibition of poly(ADP-ribose) polymerase-1 (PARP-1). We recently showed that interference with PARP-1 activity by NU1025 is strongly cytotoxic for BRCA1-positive BT-20 cells but not BRCA1-deficient SKBr-3 cells. These unexpecte...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Korean Society of Cancer Prevention
2014
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4204161/ https://ncbi.nlm.nih.gov/pubmed/25337581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15430/JCP.2014.19.2.125 |
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