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A Microarray-Based Antibiotic Screen Identifies a Regulatory Role for Supercoiling in the Osmotic Stress Response of Escherichia coli

Changes in DNA supercoiling are induced by a wide range of environmental stresses in Escherichia coli, but the physiological significance of these responses remains unclear. We now demonstrate that an increase in negative supercoiling is necessary for transcriptional activation of a large subset of...

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Hlavní autoři: Cheung, Kevin J., Badarinarayana, Vasudeo, Selinger, Douglas W., Janse, Daniel, Church, George M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC420364/
https://ncbi.nlm.nih.gov/pubmed/12566398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.401003
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