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Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells

Although autophagic pathways are essential to developmental processes, many questions still remain regarding the initiation signals that regulate autophagy in the context of differentiation. To address these questions we studied the ocular lens, as the programmed elimination of nuclei and organelles...

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Библиографические подробности
Главные авторы: Basu, Subhasree, Rajakaruna, Suren, Reyes, Beverly, Van Bockstaele, Elisabeth, Menko, A Sue
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203547/
https://ncbi.nlm.nih.gov/pubmed/24813396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28768
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