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AP4 is required for mitogen- and c-MYC-induced cell cycle progression

AP4 represents a c-MYC-inducible bHLH-LZ transcription factor, which displays elevated expression in many types of tumors. We found that serum-starved AP4-deficient mouse embryo fibroblasts (MEFs) were unable to resume proliferation and showed a delayed S-phase entry after restimulation. Furthermore...

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Detalhes bibliográficos
Main Authors: Jackstadt, Rene, Hermeking, Heiko
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4202125/
https://ncbi.nlm.nih.gov/pubmed/25261373
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