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AP4 encodes a c-MYC-inducible repressor of p21

In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive. Here, we report that c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. Induction of AP4 was required for c-MYC-mediated cell cycle reentry of anti-estrogen arre...

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Bibliografiske detaljer
Main Authors: Jung, Peter, Menssen, Antje, Mayr, Doris, Hermeking, Heiko
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553359/
https://ncbi.nlm.nih.gov/pubmed/18818310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801773105
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