Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway

Up-regulation of placental soluble fms-like tyrosine kinase 1 (sFlt1) contributes to the pathogenesis of preeclampsia. To evaluate novel upstream pathways that regulate placental sFlt1 production, we screened a library of natural compounds (n=502) in human placental cell lines. Here, we report 3 com...

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Autori principali: Rana, Sarosh, Rajakumar, Augustine, Geahchan, Carl, Salahuddin, Saira, Cerdeira, Ana Sofia, Burke, Suzanne D., George, Eric M., Granger, Joey P., Karumanchi, S. Ananth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2014
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4202104/
https://ncbi.nlm.nih.gov/pubmed/24970393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-252684
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