The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity

Bcl-3 is an atypical member of the IκB family and modulates gene expression via interaction with p50/NF-κB1 or p52/NF-κB2 homodimers. We report here that Bcl-3 is required in dendritic cells (DCs) to assure effective priming of CD4 and CD8 T cells. Lack of Bcl-3 in bone marrow-derived DCs (BMDCs) bl...

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Huvudupphovsmän: Tassi, Ilaria, Claudio, Estefania, Wang, Hongshan, Tang, Wanhu, Ha, Hye-lin, Saret, Sun, Ramaswamy, Madhu, Siegel, Richard, Siebenlist, Ulrich
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201953/
https://ncbi.nlm.nih.gov/pubmed/25246497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401505
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