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The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity
Bcl-3 is an atypical member of the IκB family and modulates gene expression via interaction with p50/NF-κB1 or p52/NF-κB2 homodimers. We report here that Bcl-3 is required in dendritic cells (DCs) to assure effective priming of CD4 and CD8 T cells. Lack of Bcl-3 in bone marrow-derived DCs (BMDCs) bl...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4201953/ https://ncbi.nlm.nih.gov/pubmed/25246497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401505 |
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