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Mass spectrometry in cancer biomarker research: a case for immunodepletion of abundant blood-derived proteins from clinical tissue specimens

The discovery of clinically relevant cancer biomarkers using mass spectrometry (MS)-based proteomics has proven difficult, primarily because of the enormous dynamic range of blood-derived protein concentrations and the fact that the 22 most abundant blood-derived proteins constitute approximately 99...

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Hlavní autoři: Prieto, DaRue A, Johann, Donald J, Wei, Bih-Rong, Ye, Xiaoying, Chan, King C, Nissley, Dwight V, Simpson, R Mark, Citrin, Deborah E, Mackall, Crystal L, Linehan, W Marston, Blonder, Josip
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201940/
https://ncbi.nlm.nih.gov/pubmed/24521024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/bmm.13.101
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