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Solution NMR studies reveal no global flexibility in the catalytic domain of CDC25B

The CDC25B phosphatase is a critical regulator of the cell cycle and has been validated as an important therapeutic target in cancer. Previous studies using molecular dynamics simulations have concluded that the catalytic domain of CDC25B may experience a significant degree of dynamics or be partial...

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Detalhes bibliográficos
Main Authors: Lund, George, Cierpicki, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201642/
https://ncbi.nlm.nih.gov/pubmed/24740794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24581
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