Synthesis and Biological Evaluation of 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indoles as Potent Histone Deacetylase Inhibitors with Antitumor Activity in Vivo

[Image: see text] A series of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles has been identified as a new class of histone deacetylase inhibitors. Compounds 8, 11, 12, 13, and 14 demonstrated stronger antiproliferative activities than 1 (SAHA) with GI(50) values ranging from 0.36 to 1.21 μM against H...

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Detalhes bibliográficos
Principais autores: Lai, Mei-Jung, Huang, Han-Li, Pan, Shiow-Lin, Liu, Yi-Min, Peng, Chieh-Yu, Lee, Hsueh-Yun, Yeh, Teng-Kuang, Huang, Po-Hsien, Teng, Che-Ming, Chen, Ching-Shih, Chuang, Hsun-Yueh, Liou, Jing-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201585/
https://ncbi.nlm.nih.gov/pubmed/22439863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300197a
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