The Procognitive and Synaptogenic Effects of Angiotensin IV–Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System

A subset of angiotensin IV (AngIV)–related molecules are known to possess procognitive/antidementia properties and have been considered as templates for potential therapeutics. However, this potential has not been realized because of two factors: 1) a lack of blood-brain barrier–penetrant analogs, a...

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Bibliographic Details
Main Authors: Benoist, Caroline C., Kawas, Leen H., Zhu, Mingyan, Tyson, Katherine A., Stillmaker, Lori, Appleyard, Suzanne M., Wright, John W., Wayman, Gary A., Harding, Joseph W.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2014
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201273/
https://ncbi.nlm.nih.gov/pubmed/25187433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.218735
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