The Limitations of Diazepam as a Treatment for Nerve Agent–Induced Seizures and Neuropathology in Rats: Comparison with UBP302

Exposure to nerve agents induces prolonged status epilepticus (SE), causing brain damage or death. Diazepam (DZP) is the current US Food and Drug Administration–approved drug for the cessation of nerve agent–induced SE. Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzy...

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Detalhes bibliográficos
Main Authors: Apland, James P., Aroniadou-Anderjaska, Vassiliki, Figueiredo, Taiza H., Rossetti, Franco, Miller, Steven L., Braga, Maria F. M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201270/
https://ncbi.nlm.nih.gov/pubmed/25157087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.217299
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