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Endoxifen and Other Metabolites of Tamoxifen Inhibit Human Hydroxysteroid Sulfotransferase 2A1 (hSULT2A1)

Although tamoxifen is a successful agent for treatment and prevention of estrogen-dependent breast cancer, its use has been limited by the low incidence of endometrial cancer. Human hydroxysteroid sulfotransferase 2A1 (hSULT2A1) catalyzes the formation of an α-sulfooxy metabolite of tamoxifen that i...

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Detalhes bibliográficos
Main Authors: Squirewell, Edwin J., Qin, Xiaoyan, Duffel, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201133/
https://ncbi.nlm.nih.gov/pubmed/25157097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.059709
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