Endothelin-1 Promotes Myofibroblast Induction through the ETA Receptor via a rac/Phosphoinositide 3-Kinase/Akt-dependent Pathway and Is Essential for the Enhanced Contractile Phenotype of Fibrotic Fibroblasts

The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence contributing to matrix remodeling during tissue repair. H...

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Autors principals: Shi-Wen, Xu, Chen, Yunliang, Denton, Christopher P., Eastwood, Mark, Renzoni, Elisabetta A., Bou-Gharios, George, Pearson, Jeremy D., Dashwood, Michael, du Bois, Roland M., Black, Carol M., Leask, Andrew, Abraham, David J
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2004
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC420095/
https://ncbi.nlm.nih.gov/pubmed/15047866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-12-0902
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