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Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts

BACKGROUND: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix and produce α−smooth muscle actin (α-SMA), type...

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Autori principali: Shi-wen, Xu, Liu, Shangxi, Eastwood, Mark, Sonnylal, Sonali, Denton, Christopher P., Abraham, David J., Leask, Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757676/
https://ncbi.nlm.nih.gov/pubmed/19823586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007438
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