Matrix Contraction by Dermal Fibroblasts Requires Transforming Growth Factor-β/Activin-Linked Kinase 5, Heparan Sulfate-Containing Proteoglycans, and MEK/ERK : Insights into Pathological Scarring in Chronic Fibrotic Disease

Scarring is characterized by excessive synthesis and contraction of extracellular matrix. Here, we show that fibroblasts from scarred (lesional) areas of patients with the chronic fibrotic disorder diffuse scleroderma [diffuse systemic sclerosis (dSSc)] show an enhanced ability to adhere to and cont...

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Detalhes bibliográficos
Main Authors: Chen, Yunliang, Shi-wen, Xu, van Beek, Jonathan, Kennedy, Laura, McLeod, Marilyn, Renzoni, Elisabetta A., Bou-Gharios, George, Wilcox-Adelman, Sarah, Goetinck, Paul F., Eastwood, Mark, Black, Carol M., Abraham, David J., Leask, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2005
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1613194/
https://ncbi.nlm.nih.gov/pubmed/16314481
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