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Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment
We report a new inflammatory activity for extracellular d-dopachrome tautomerase (D-DT), the recruitment of neutrophils to the lung on D-DT intratracheal installation of C57BL/6J mice with an EC(50) of 5.6 μg. We also find that D-DT and macrophage migration inhibitory factor (MIF) have additive effe...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Federation of American Societies for Experimental Biology
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4200328/ https://ncbi.nlm.nih.gov/pubmed/25016026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-256636 |
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