Renal medullary cyclooxygenase-2 and (pro)renin receptor expression during angiotensin II-dependent hypertension

The (pro)renin receptor [(P)RR] upregulates cyclooxygenase-2 (COX-2) in inner medullary collecting duct (IMCD) cells through ERK1/2. Intrarenal COX-2 and (P)RR are upregulated during chronic ANG II infusion. However, the duration of COX-2 and (P)RR upregulation has not been determined. We hypothesiz...

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Autors principals: Gonzalez, Alexis A., Green, Torrance, Luffman, Christina, Bourgeois, Camille R. T., Gabriel Navar, L., Prieto, Minolfa C.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200301/
https://ncbi.nlm.nih.gov/pubmed/25143455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00267.2014
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