Synthetic Phosphopeptides Enable Quantitation of the Content and Function of the Four Phosphorylation States of Phospholamban in Cardiac Muscle

We have studied the differential effects of phospholamban (PLB) phosphorylation states on the activity of the sarcoplasmic reticulum Ca-ATPase (SERCA). It has been shown that unphosphorylated PLB (U-PLB) inhibits SERCA and that phosphorylation of PLB at Ser-16 or Thr-17 relieves this inhibition in c...

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Detalhes bibliográficos
Main Authors: Ablorh, Naa-Adjeley D., Dong, Xiaoqiong, James, Zachary M., Xiong, Qiang, Zhang, Jianyi, Thomas, David D., Karim, Christine B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200288/
https://ncbi.nlm.nih.gov/pubmed/25190804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.556621
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