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Short Forms of Ste20-related Proline/Alanine-rich Kinase (SPAK) in the Kidney Are Created by Aspartyl Aminopeptidase (Dnpep)-mediated Proteolytic Cleavage

The Ste20-related kinase SPAK regulates sodium, potassium, and chloride transport in a variety of tissues. Recently, SPAK fragments, which lack the catalytic domain and are inhibitory to Na(+) transporters, have been detected in kidney. It has been hypothesized that the fragments originate from alte...

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Autori principali: Markadieu, Nicolas, Rios, Kerri, Spiller, Benjamin W., McDonald, W. Hayes, Welling, Paul A., Delpire, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200278/
https://ncbi.nlm.nih.gov/pubmed/25164821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604009
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