Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1

Targeted degradation of proteins through the ubiquitin-proteasome system (UPS) via the activities of E3 ubiquitin ligases regulates diverse cellular processes, and misregulation of these enzymes contributes to the pathogenesis of human diseases. One of the challenges facing the UPS field is to delin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Thompson, Joel W., Nagel, Jane, Hoving, Sjouke, Gerrits, Bertran, Bauer, Andreas, Thomas, Jason R., Kirschner, Marc W., Schirle, Markus, Luchansky, Sarah J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200252/
https://ncbi.nlm.nih.gov/pubmed/25147182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.573352
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados