Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1

Targeted degradation of proteins through the ubiquitin-proteasome system (UPS) via the activities of E3 ubiquitin ligases regulates diverse cellular processes, and misregulation of these enzymes contributes to the pathogenesis of human diseases. One of the challenges facing the UPS field is to delin...

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Detaylı Bibliyografya
Asıl Yazarlar: Thompson, Joel W., Nagel, Jane, Hoving, Sjouke, Gerrits, Bertran, Bauer, Andreas, Thomas, Jason R., Kirschner, Marc W., Schirle, Markus, Luchansky, Sarah J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2014
Konular:
Protein Synthesis and Degradation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200252/
https://ncbi.nlm.nih.gov/pubmed/25147182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.573352
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