Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcoma

BACKGROUND: Increasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, such as tyrosine kinase inhibitors (TKIs). We hypothesized that TKIs would have...

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Detalhes bibliográficos
Main Authors: Canter, Robert J, Ames, Erik, Mac, Stephanie, Grossenbacher, Steven K, Chen, Mingyi, Li, Chin-Shang, Borys, Dariusz, Smith, Rachel C, Tellez, Joe, Sayers, Thomas J, Monjazeb, Arta M, Murphy, William J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200119/
https://ncbi.nlm.nih.gov/pubmed/25301268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-756
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