Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role

BACKGROUND: Polycomb group (PcG) proteins are histone modifiers known to transcriptionally silence key tumour suppressor genes in multiple human cancers. The chromobox proteins (CBX2, 4, 6, 7, and 8) are critical components of PcG-mediated repression. Four of them have been associated with tumour bi...

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Detalhes bibliográficos
Main Authors: Clermont, P-L, Sun, L, Crea, F, Thu, K L, Zhang, A, Parolia, A, Lam, W L, Helgason, C D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200100/
https://ncbi.nlm.nih.gov/pubmed/25225902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.474
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