Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration

BACKGROUND: Polycomb group genes (PcGs) are epigenetic effectors implicated in most cancer hallmarks. The mutational status of all PcGs has never been systematically assessed in solid tumours. METHODS: We conducted a multi-step analysis on publically available databases and patient samples to identi...

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Detalhes bibliográficos
Main Authors: Crea, F, Sun, L, Pikor, L, Frumento, P, Lam, W L, Helgason, C D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776977/
https://ncbi.nlm.nih.gov/pubmed/23942079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.454
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