Mammalian Polyhomeotic Homologues Phc2 and Phc1 Act in Synergy To Mediate Polycomb Repression of Hox Genes

The Polycomb group (PcG) gene products form multimeric protein complexes and contribute to anterior-posterior (A-P) specification via the transcriptional regulation of Hox cluster genes. The Drosophila polyhomeotic genes and their mammalian orthologues, Phc1, Phc2, and Phc3, encode nuclear proteins...

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Autores principales: Isono, Kyo-ichi, Fujimura, Yu-ichi, Shinga, Jun, Yamaki, Makoto, O-Wang, Jiyang, Takihara, Yoshihiro, Murahashi, Yasuaki, Takada, Yuki, Mizutani-Koseki, Yoko, Koseki, Haruhiko
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2005
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190356/
https://ncbi.nlm.nih.gov/pubmed/16024804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6694-6706.2005
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