Glial TLR4 signaling does not contribute to opioid-induced depression of respiration

Opioids activate glia in the central nervous system in part by activating the toll-like receptor 4 (TLR4)/myeloid differentiation 2 (MD2) complex. TLR4/MD2-mediated activation of glia by opioids compromises their analgesic actions. Glial activation is also hypothesized as pivotal in opioid-mediated...

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Hlavní autoři: Zwicker, Jennifer D., Zhang, Yong, Ren, Jun, Hutchinson, Mark R., Rice, Kenner C., Watkins, Linda R., Greer, John J., Funk, Gregory D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199989/
https://ncbi.nlm.nih.gov/pubmed/25103966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00534.2014
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