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Glial TLR4 signaling does not contribute to opioid-induced depression of respiration
Opioids activate glia in the central nervous system in part by activating the toll-like receptor 4 (TLR4)/myeloid differentiation 2 (MD2) complex. TLR4/MD2-mediated activation of glia by opioids compromises their analgesic actions. Glial activation is also hypothesized as pivotal in opioid-mediated...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Physiological Society
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4199989/ https://ncbi.nlm.nih.gov/pubmed/25103966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00534.2014 |
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