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Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes

Nitrogen mustard (NM), a structural analog of chemical warfare agent sulfur mustard (SM), forms adducts and crosslinks with DNA, RNA and proteins. Here we studied the mechanism of NM-induced skin toxicity in response to double strand breaks (DSBs) resulting in cell cycle arrest to facilitate DNA rep...

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Bibliografiske detaljer
Main Authors: Inturi, Swetha, Tewari-Singh, Neera, Agarwal, Chapla, White, Carl W., Agarwal, Rajesh
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199943/
https://ncbi.nlm.nih.gov/pubmed/24732344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2014.04.002
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