Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts

Employing mouse skin epidermal JB6 cells and dermal fibroblasts, here we examined the mechanisms of DNA damage by 2-chloroethyl ethyl sulfide (CEES), a monofunctional analog of sulfur mustard (SM). CEES exposure caused H2A.X and p53 phosphorylation as well as p53 accumulation in both cell types, sta...

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Detalhes bibliográficos
Main Authors: Inturi, Swetha, Tewari-Singh, Neera, Gu, Mallikarjuna, Shrotriya, Sangeeta, Gomez, Joe, Agarwal, Chapla, White, Carl W., Agarwal, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662483/
https://ncbi.nlm.nih.gov/pubmed/21920433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.08.020
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