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Effects of Cytochrome P450 2C19 and Paraoxonase 1 Polymorphisms on Antiplatelet Response to Clopidogrel Therapy in Patients with Coronary Artery Disease

Clopidogrel is an antiplatelet prodrug that is recommended to reduce the risk of recurrent thrombosis in coronary artery disease (CAD) patients. Paraoxonase 1 (PON1) is suggested to be a rate-limiting enzyme in the conversion of 2-oxo-clopidogrel to active thiol metabolite with inconsistent results....

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書誌詳細
主要な著者: Tresukosol, Damrus, Suktitipat, Bhoom, Hunnangkul, Saowalak, Kamkaew, Ruttakarn, Poldee, Saiphon, Tassaneetrithep, Boonrat, Likidlilid, Atip
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199712/
https://ncbi.nlm.nih.gov/pubmed/25329996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110188
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