Effects of Cytochrome P450 2C19 and Paraoxonase 1 Polymorphisms on Antiplatelet Response to Clopidogrel Therapy in Patients with Coronary Artery Disease

Clopidogrel is an antiplatelet prodrug that is recommended to reduce the risk of recurrent thrombosis in coronary artery disease (CAD) patients. Paraoxonase 1 (PON1) is suggested to be a rate-limiting enzyme in the conversion of 2-oxo-clopidogrel to active thiol metabolite with inconsistent results....

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Detaylı Bibliyografya
Asıl Yazarlar: Tresukosol, Damrus, Suktitipat, Bhoom, Hunnangkul, Saowalak, Kamkaew, Ruttakarn, Poldee, Saiphon, Tassaneetrithep, Boonrat, Likidlilid, Atip
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199712/
https://ncbi.nlm.nih.gov/pubmed/25329996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110188
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