Early Double-Negative Thymocyte Export in Trypanosoma cruzi Infection Is Restricted by Sphingosine Receptors and Associated with Human Chagas Disease

The protozoan parasite Trypanosoma cruzi is able to target the thymus and induce alterations of the thymic microenvironmental and lymphoid compartments. Acute infection results in severe atrophy of the organ and early release of immature thymocytes into the periphery. To date, the pathophysiological...

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Autori principali: Lepletier, Ailin, de Almeida, Liliane, Santos, Leonardo, da Silva Sampaio, Luzia, Paredes, Bruno, González, Florencia Belén, Freire-de-Lima, Célio Geraldo, Beloscar, Juan, Bottasso, Oscar, Einicker-Lamas, Marcelo, Pérez, Ana Rosa, Savino, Wilson, Morrot, Alexandre
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199546/
https://ncbi.nlm.nih.gov/pubmed/25330249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003203
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