Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease

The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymi...

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Bibliographic Details
Published in:Biomed Res Int
Main Authors: Flávia Nardy, Ana, Santos, Leonardo, Freire-de-Lima, Célio Geraldo, Morrot, Alexandre
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2015
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539443/
https://ncbi.nlm.nih.gov/pubmed/26347020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/709846
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