The DAF-16 FOXO Transcription Factor Regulates natc-1 to Modulate Stress Resistance in Caenorhabditis elegans, Linking Insulin/IGF-1 Signaling to Protein N-Terminal Acetylation

The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity, but the mechanisms are not fully characterized. To identify genes that mediate stress resistance, we screened for C. elegans mutants that can tolerate high levels of dietary zinc. We identified natc-1, whic...

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Bibliographische Detailangaben
Hauptverfasser: Warnhoff, Kurt, Murphy, John T., Kumar, Sandeep, Schneider, Daniel L., Peterson, Michelle, Hsu, Simon, Guthrie, James, Robertson, J. David, Kornfeld, Kerry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199503/
https://ncbi.nlm.nih.gov/pubmed/25330323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004703
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