The DAF-16 FOXO Transcription Factor Regulates natc-1 to Modulate Stress Resistance in Caenorhabditis elegans, Linking Insulin/IGF-1 Signaling to Protein N-Terminal Acetylation

The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity, but the mechanisms are not fully characterized. To identify genes that mediate stress resistance, we screened for C. elegans mutants that can tolerate high levels of dietary zinc. We identified natc-1, whic...

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Detalhes bibliográficos
Main Authors: Warnhoff, Kurt, Murphy, John T., Kumar, Sandeep, Schneider, Daniel L., Peterson, Michelle, Hsu, Simon, Guthrie, James, Robertson, J. David, Kornfeld, Kerry
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199503/
https://ncbi.nlm.nih.gov/pubmed/25330323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004703
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