Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4)

Interferon lambda 4 gene (IFNL4) encodes IFN-λ4, a new member of the IFN-λ family with antiviral activity. In humans IFNL4 open reading frame is truncated by a polymorphic frame-shift insertion that eliminates IFN-λ4 and turns IFNL4 into a polymorphic pseudogene. Functional IFN-λ4 has antiviral acti...

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Main Authors: Key, Felix M., Peter, Benjamin, Dennis, Megan Y., Huerta-Sánchez, Emilia, Tang, Wei, Prokunina-Olsson, Ludmila, Nielsen, Rasmus, Andrés, Aida M.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199494/
https://ncbi.nlm.nih.gov/pubmed/25329461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004681
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