Akt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis

Although recent evidence supports a tumor-suppressive role for the GTPase RhoB, little is known about its regulation by signal transduction pathways. Here we demonstrate that Ras downregulates RhoB expression by a phosphatidylinositol 3-kinase (PI3K)- and Akt- but not Mek-dependent mechanism. Furthe...

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Bibliografiske detaljer
Main Authors: Jiang, Kun, Sun, Jiazhi, Cheng, Jin, Djeu, Julie Y., Wei, Sheng, Sebti, Saïd
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC419878/
https://ncbi.nlm.nih.gov/pubmed/15169915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.12.5565-5576.2004
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