Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia

Deregulation of the miR-15a/16-1 cluster has a key role in the pathogenesis of chronic lymphocytic leukemia (CLL), a clinically heterogeneous disease with indolent and aggressive forms. The miR-15a/16-1 locus is located at 13q14, the most frequently deleted region in CLL. Starting from functional in...

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Hauptverfasser: Veronese, A, Pepe, F, Chiacchia, J, Pagotto, S, Lanuti, P, Veschi, S, Di Marco, M, D'Argenio, A, Innocenti, I, Vannata, B, Autore, F, Marchisio, M, Wernicke, D, Verginelli, F, Leone, G, Rassenti, L Z, Kipps, T J, Mariani-Costantini, R, Laurenti, L, Croce, C M, Visone, R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198514/
https://ncbi.nlm.nih.gov/pubmed/24732594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.139
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