Hydrogen sulfide mitigates hyperglycemic remodeling via liver kinase B1-adenosine monophosphate-activated protein kinase signaling

Hyperglycemia (HG) reduces AMPK activation leading to impaired autophagy and matrix accumulation. Hydrogen sulfide (H(2)S) treatment improves HG-induced renovascular remodeling however, its mechanism remains unclear. Activation of LKB1 by the formation of heterotrimeric complex with STRAD and MO25 i...

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Главные авторы: Kundu, Sourav, Pushpakumar, Sathnur, Khundmiri, Syed J., Sen, Utpal
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198479/
https://ncbi.nlm.nih.gov/pubmed/25127936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2014.08.005
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