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Gamma Secretase Inhibitors enhance Vincristine-induced apoptosis in T-ALL in a NOTCH-independent manner
BACKGROUND: Activating mutations in the NOTCH1 gene are found in over 50% of T-ALL cases. Since Notch signaling contributes to the leukemia cell survival and growth, targeting Notch signaling using γ-secretase inhibitors (GSI) has been proposed as a molecularly targeted therapy for the treatment of...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4198427/ https://ncbi.nlm.nih.gov/pubmed/25156146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-014-1029-5 |
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