Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent

Chloroquine (CQ) is an antimalarial drug and late-stage inhibitor of autophagy currently FDA-approved for use in the treatment of rheumatoid arthritis and other autoimmune diseases. Based primarily on its ability to inhibit autophagy, CQ and its derivative, hydroxychloroquine, are currently being in...

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Bibliografiska uppgifter
Huvudupphovsmän: Morgan, Michael J, Gamez, Graciela, Menke, Christina, Hernandez, Ariel, Thorburn, Jacqueline, Gidan, Freddi, Staskiewicz, Leah, Morgan, Shellie, Cummings, Christopher, Maycotte, Paola, Thorburn, Andrew
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2014
Ämnen:
Basic Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198365/
https://ncbi.nlm.nih.gov/pubmed/25136801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.32135
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